LMPD Database

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LMP012831

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-5-phosphate 4-kinase, type II, beta
Protein EntryPI42B_RAT
UniProt IDO88377
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
FunctionParticipates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate
PtmPhosphorylated on serine residues. Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels (By similarity)
SimilarityContains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein . Cell membrane {ECO:0000250}; Peripheral membrane protein . Nucleus {ECO:0000250}. Cytoplasm . Note=Associated with the plasma membrane and the endoplasmic reticulum
SubunitHomodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex (By similarity)