LMPD Database

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LMP012852

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate-5-phosphatase E
Protein Entry
UniProt ID
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. {ECO:0000269|PubMed:10405344}.
CautionThe N-terminus was extended using the genomic sequence, in analogy to ortholog sequences. {ECO:0000305}.
FunctionConverts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5- bisphosphate to phosphatidylinositol 4-phosphate. Can convert lipid substrates, but also water soluble inositol phosphates. {ECO:0000269|PubMed:10405344}.
Sequence CautionSequence=BAA82150.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the inositol 1,4,5-trisphosphate 5- phosphatase type IV family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9JII1}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000269|PubMed:10405344}; Peripheral membrane protein {ECO:0000269|PubMed:10405344}; Cytoplasmic side {ECO:0000269|PubMed:10405344}. Cell projection, ruffle {ECO:0000269|PubMed:10405344}. Cytoplasm {ECO:0000269|PubMed:10405344}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000250|UniProtKB:Q9JII1}.
SubunitInteracts (when prenylated) with PDE6D; this is important for normal location in cilia. {ECO:0000250|UniProtKB:Q9NRR6}.