LMPD Database

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LMP012870

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member B7
Protein EntryALD1_RAT
UniProt IDQ5RJP0
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=1.5 uM for NADPH {ECO:0000269|PubMed:21048316, ECO:0000269|PubMed:21168333}; KM=220 uM for NADH {ECO:0000269|PubMed:21048316, ECO:0000269|PubMed:21168333}; KM=0.16 uM for 4-oxo-2-nonenal {ECO:0000269|PubMed:21048316, ECO:0000269|PubMed:21168333}; KM=37 uM for geraniol {ECO:0000269|PubMed:21048316, ECO:0000269|PubMed:21168333}; KM=1.5 uM for 4-nitrobenzaldehyde {ECO:0000269|PubMed:21048316, ECO:0000269|PubMed:21168333}; pH dependence: Optimum pH is 6.5-7. {ECO:0000269|PubMed:21048316, ECO:0000269|PubMed:21168333};
Catalytic ActivityAlditol + NAD(P)(+) = aldose + NAD(P)H
Enzyme RegulationInhibited by tolrestat and epalrestat
FunctionReduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. May play a role in the metabolism of xenobiotic aromatic aldehydes
SimilarityBelongs to the aldo/keto reductase family
Subcellular LocationCytoplasm .
SubunitMonomer