LMPD Database

LMP012876

Gene Information

Entrez Gene ID	116643
Gene Name	valosin-containing protein
Gene Symbol	Vcp
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	IDA:MGI	C	cytosol
GO:0005783	IDA:RGD	C	endoplasmic reticulum
GO:0070062	IEA:Ensembl	C	extracellular vesicular exosome
GO:0000836	IEA:Ensembl	C	Hrd1p ubiquitin ligase complex
GO:0043231	IDA:RGD	C	intracellular membrane-bounded organelle
GO:0005811	IEA:Ensembl	C	lipid particle
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0000502	IEA:Ensembl	C	proteasome complex
GO:0035861	ISS:UniProtKB	C	site of double-strand break
GO:0043531	IMP:RGD	F	ADP binding
GO:0016887	IDA:RGD	F	ATPase activity
GO:0005524	IDA:BHF-UCL	F	ATP binding
GO:0035800	IEA:Ensembl	F	deubiquitinase activator activity
GO:0042802	IDA:BHF-UCL	F	identical protein binding
GO:0008289	IEA:UniProtKB-KW	F	lipid binding
GO:0044822	IEA:Ensembl	F	poly(A) RNA binding
GO:0032403	IPI:RGD	F	protein complex binding
GO:0005102	IDA:RGD	F	receptor binding
GO:0006919	IEA:Ensembl	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070842	IEA:Ensembl	P	aggresome assembly
GO:0006200	IDA:GOC	P	ATP catabolic process
GO:0006974	ISS:UniProtKB	P	cellular response to DNA damage stimulus
GO:0006302	ISS:UniProtKB	P	double-strand break repair
GO:0030433	ISS:UniProtKB	P	ER-associated ubiquitin-dependent protein catabolic process
GO:0006888	IMP:RGD	P	ER to Golgi vesicle-mediated transport
GO:1903007	IEA:Ensembl	P	positive regulation of Lys63-specific deubiquitinase activity
GO:0032436	IMP:RGD	P	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031334	IEA:Ensembl	P	positive regulation of protein complex assembly
GO:1903006	IEA:Ensembl	P	positive regulation of protein K63-linked deubiquitination
GO:0034214	IDA:RGD	P	protein hexamerization
GO:0051260	IDA:RGD	P	protein homooligomerization
GO:0018279	ISS:UniProtKB	P	protein N-linked glycosylation via asparagine
GO:0016567	ISS:UniProtKB	P	protein ubiquitination
GO:0030970	IEA:Ensembl	P	retrograde protein transport, ER to cytosol
GO:0019985	ISS:UniProtKB	P	translesion synthesis

KEGG Pathway Links

KEGG Pathway ID	Description
M00403	HRD1/SEL1 ERAD complex
ko05134	Legionellosis
rno05134	Legionellosis
M00400	p97-Ufd1-Npl4 complex
ko04141	Protein processing in endoplasmic reticulum
rno04141	Protein processing in endoplasmic reticulum

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953238	Cellular responses to stress
5954621	Cellular response to heat stress
5953253	Disease
5954643	Hedgehog ligand biogenesis
5954646	Hh ligand biogenesis disease
5954622	HSF1 activation
5954645	Processing-defective Hh variants abrogate ligand secretion
5954644	Signaling by Hedgehog
5953381	Signal Transduction