LMPD Database

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LMP012885

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Protein EntryP3C2G_RAT
UniProt IDO70173
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
Developmental StageHigher levels of expression found in adult liver than in fetal liver
FunctionGenerates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity)
SimilarityBelongs to the PI3/PI4-kinase family. {ECO:0000255|PROSITE-ProRule:PRU00879, ECO:0000255|PROSITE- ProRule:PRU00880}.
SimilarityContains 1 C2 domain
SimilarityContains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE- ProRule:PRU00880}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 1 PI3K-RBD domain. {ECO:0000255|PROSITE- ProRule:PRU00879}.
SimilarityContains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
SimilarityContains 1 PX (phox homology) domain
Subcellular LocationMembrane ; Peripheral membrane protein .
Tissue SpecificityPredominantly expressed in normal liver. High levels also found in regenerating liver. Very low levels found in heart and testis