LMPD Database

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LMP012903

UniProt Annotations

Entry Information
Gene Namephosphate cytidylyltransferase 1, choline, alpha
Protein EntryPCY1A_RAT
UniProt IDP19836
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityCTP + phosphocholine = diphosphate + CDP- choline. {ECO:0000269|PubMed:12718547, ECO:0000269|PubMed:19783652}.
Enzyme RegulationBy phosphorylation.
FunctionControls phosphatidylcholine synthesis.
MiscellaneousThe cytidylyltransferase may interact with membranes through its amphipathic helix.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
PtmMonoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation
PtmThe N-terminus is blocked.
PtmThe serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation
SimilarityBelongs to the cytidylyltransferase family
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:639816}. Membrane ; Peripheral membrane protein . Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form.
SubunitHomodimer