LMPD Database

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LMP012908

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, alpha
Protein EntryDGKA_RAT
UniProt IDP51556
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme RegulationStimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C (By similarity)
FunctionUpon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.
SimilarityBelongs to the eukaryotic diacylglycerol kinase family
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
SimilarityContains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers
SubunitMonomer
Tissue SpecificityLymphocytes and oligodendroglial cells.