LMPD Database

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LMP012918

UniProt Annotations

Entry Information
Gene Nameacyl-CoA thioesterase 12
Protein EntryACO12_RAT
UniProt IDQ99NB7
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + H(2)O = CoA + acetate.
Enzyme RegulationAllosterically regulated by ATP (activator) and ADP (inhibitor).
FunctionHydrolyzes acetyl-CoA to acetate and CoA.
InductionBy 2-(p-chlorophenoxy)isobutyric acid (CPIB).
PathwayCarbohydrate metabolism; pyruvate metabolism.
SimilarityContains 1 START domain. {ECO:0000255|PROSITE- ProRule:PRU00197}.
SimilarityContains 2 acyl coenzyme A hydrolase domains
Subcellular LocationCytoplasm.
SubunitActive homodimer or homotetramer at room temperature and inactive monomer at low temperature.