LMPD Database

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LMP012927

UniProt Annotations

Entry Information
Gene Nameserine incorporator 5
Protein EntrySERC5_RAT
UniProt IDQ63175
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q63175-1; Sequence=Displayed; Name=2; IsoId=Q63175-2; Sequence=VSP_033056;
Developmental StageFirst detected in significant amounts at postnatal day 2 (P2) and increases about twofold to a peak value at P17-P20 and declines significantly thereafter
FunctionEnhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes. {ECO:0000269|PubMed:16120614, ECO:0000269|PubMed:9326262}.
InductionUp-regulated during the differentiation of oligodendrocyte lineage cells and during brain development at the time of myelination. Down-regulated in the hippocampal CA fields and dentate gyrus by seizures. {ECO:0000269|PubMed:16120614, ECO:0000269|PubMed:9326262}.
SimilarityBelongs to the TDE1 family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
Tissue SpecificityBrain. Expressed at high levels in the white matter and the oligodendroglial cells of the brain. Expressed at low levels in the liver. {ECO:0000269|PubMed:16120614, ECO:0000269|PubMed:9326262}.