LMPD Database

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LMP012933

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate-5-phosphatase J
Protein EntryPI5PA_RAT
UniProt IDQ9JMC1
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
Catalytic ActivityD-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate
DomainThe 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.
FunctionInositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles.
PtmPhosphorylated on Ser/Thr residues.
SimilarityBelongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family
Subcellular LocationCytoplasm . Note=Predominantly localized to membrane ruffles.
Tissue SpecificityExpressed in heart, brain, kidney, stomach, small intestine and lung. Not expressed in spleen, thymus, skeletal muscle, testis and skin