LMPD Database

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LMP012947

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
Protein EntryARK72_RAT
UniProt IDQ8CG45
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: Note=Has a low KM for succinic semialdehyde.;
Catalytic Activity4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH.
FunctionCatalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein- binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Acts as a 2-carboxybenzaldehyde reductase
MiscellaneousWith 4-nitrobenzaldehyde as substrate, it exhibits a substantially greater specic activity with NADPH than with NADH. Conversely, it has a 1.8-fold higher activity towards succinic semialdehyde with NADH than with NADPH.
Sequence CautionSequence=AAH61816.1; Type=Erroneous initiation; Evidence= ; Sequence=BAA90396.1; Type=Erroneous initiation; Evidence= ; Sequence=CAC81080.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily
Subcellular LocationGolgi apparatus, Golgi stack . Cytoplasm . Note=Its association with the Golgi stack may facilitate secretion of GHB.
SubunitHomodimer. Heterodimer with AKR7A1