LMPD Database

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LMP012961

UniProt Annotations

Entry Information
Gene NameCDP-diacylglycerol--inositol 3-phosphatidyltransferase
Protein EntryCDIPT_RAT
UniProt IDP70500
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityCDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol. {ECO:0000269|PubMed:3032971, ECO:0000269|PubMed:7998949}.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:3032971, ECO:0000269|PubMed:7998949}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:3032971, ECO:0000269|PubMed:7998949}; Note=Divalent metal cations; Mn(2+) or Mg(2+) (PubMed:3032971). According to PubMed:7998949 the cofactor is Mn(2+), while Mg(2+) is much less effective. {ECO:0000269|PubMed:3032971, ECO:0000269|PubMed:7998949};
FunctionCatalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme
InductionInhibited by PtdIns (product inhibition).
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-I family
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane.
Tissue SpecificityDetected in liver (at protein level). Widely expressed. Highly expressed in the brain and kidney; lower levels in heart, spleen, lung, liver, skeletal muscle and testis