LMPD Database

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LMP012981

UniProt Annotations

Entry Information
Gene Namediacylglycerol O-acyltransferase 2
Protein EntryDGAT2_RAT
UniProt IDQ5FVP8
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Catalytic ActivityAcyl-CoA + retinol = CoA + retinyl ester.
Enzyme RegulationInhibited by niacin
FunctionEssential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity)
PathwayGlycerolipid metabolism; triacylglycerol biosynthesis.
SimilarityBelongs to the diacylglycerol acyltransferase family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . Lipid droplet .
SubunitForms multimeric complexes consisting of several DGAT2 subunits