LMPD Database

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LMP012989

UniProt Annotations

Entry Information
Gene Namearachidonate 15-lipoxygenase, type B
Protein EntryLX15B_RAT
UniProt IDQ8K4F2
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityArachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)- 15-hydroperoxyicosa-5,8,11,13-tetraenoate
Catalytic ActivityLinoleate + O(2) = (9Z,11E)-13- hydroxyoctadeca-9,11-dienoate
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
DomainThe PLAT domain can bind calcium ions; this promotes association with membranes
FunctionNon-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells
PathwayLipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
SimilarityBelongs to the lipoxygenase family
SimilarityContains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationCytoplasm, cytosol . Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton . Nucleus {ECO:0000250}. Membrane ; Peripheral membrane protein . Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding