LMPD Database

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LMP013005

UniProt Annotations

Entry Information
Gene Nameglucosaminyl (N-acetyl) transferase 3, mucin type
Protein EntryGCNT3_RAT
UniProt IDQ8CH87
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 7-8.5. ;
Catalytic ActivityUDP-N-acetyl-D-glucosamine + beta-D- galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D- galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-R.
Catalytic ActivityUDP-N-acetyl-D-glucosamine + beta-D- galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D- glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.
FunctionGlycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
PathwayProtein modification; protein glycosylation.
PtmN-glycosylated
SimilarityBelongs to the glycosyltransferase 14 family
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .