LMPD Database

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LMP013012

Gene Information

Entrez Gene ID287454
Gene Namearachidonate 12-lipoxygenase
Gene SymbolAlox12
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0005829 IDA:RGDCcytosol
GO:0070062 IEA:EnsemblCextracellular vesicular exosome
GO:0016020 ISS:UniProtKBCmembrane
GO:0042383 ISS:UniProtKBCsarcolemma
GO:0004052 IMP:RGDFarachidonate 12-lipoxygenase activity
GO:0016787 IEA:UniProtKB-KWFhydrolase activity
GO:0005506 IEA:InterProFiron ion binding
GO:0016165 IEA:EnsemblFlinoleate 13S-lipoxygenase activity
GO:0007568 IEP:RGDPaging
GO:0019369 IDA:UniProtKBParachidonic acid metabolic process
GO:0006928 IEA:EnsemblPcellular component movement
GO:0071396 IEP:RGDPcellular response to lipid
GO:0061436 ISS:UniProtKBPestablishment of skin barrier
GO:0019395 IEA:EnsemblPfatty acid oxidation
GO:0051122 IDA:UniProtKBPhepoxilin biosynthetic process
GO:1901751 ISS:UniProtKBPleukotriene A4 metabolic process
GO:0043651 ISS:UniProtKBPlinoleic acid metabolic process
GO:2001303 ISS:UniProtKBPlipoxin A4 biosynthetic process
GO:2001306 ISS:UniProtKBPlipoxin B4 biosynthetic process
GO:0019372 IDA:UniProtKBPlipoxygenase pathway
GO:0043066 IMP:RGDPnegative regulation of apoptotic process
GO:0010656 ISS:UniProtKBPnegative regulation of muscle cell apoptotic process
GO:0090331 ISS:UniProtKBPnegative regulation of platelet aggregation
GO:0045766 ISS:UniProtKBPpositive regulation of angiogenesis
GO:0043065 IMP:RGDPpositive regulation of apoptotic process
GO:0045785 IEA:EnsemblPpositive regulation of cell adhesion
GO:0010942 IMP:RGDPpositive regulation of cell death
GO:0030307 ISS:UniProtKBPpositive regulation of cell growth
GO:0030335 ISS:UniProtKBPpositive regulation of cell migration
GO:0008284 IMP:RGDPpositive regulation of cell proliferation
GO:0043280 IMP:RGDPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045603 IMP:RGDPpositive regulation of endothelial cell differentiation
GO:0010595 IMP:RGDPpositive regulation of endothelial cell migration
GO:0010628 IMP:RGDPpositive regulation of gene expression
GO:0051901 IMP:RGDPpositive regulation of mitochondrial depolarization
GO:0048661 IMP:RGDPpositive regulation of smooth muscle cell proliferation
GO:0045909 IMP:RGDPpositive regulation of vasodilation
KEGG Pathway Links
KEGG Pathway IDDescription
ko00590Arachidonic acid metabolism
rno00590Arachidonic acid metabolism
ko04750Inflammatory mediator regulation of TRP channels
rno04750Inflammatory mediator regulation of TRP channels
rno01100Metabolic pathways
rno04726Serotonergic synapse
REACTOME Pathway Links
REACTOME Pathway IDDescription
5953493Arachidonic acid metabolism
5953250Metabolism
5953289Metabolism of lipids and lipoproteins
5954556Synthesis of 12-eicosatetraenoic acid derivatives
5954553Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
5954552Synthesis of Lipoxins (LX)