LMPD Database

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LMP013084

UniProt Annotations

Entry Information
Gene Nameprogesterone receptor membrane component 1
Protein EntryPGRC1_RAT
UniProt IDP70580
SpeciesRat
Comments
Comment typeDescription
DomainThe cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131
FunctionReceptor for progesterone (By similarity). May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity
InductionBy dioxin.
SimilarityBelongs to the cytochrome b5 family. MAPR subfamily
SimilarityContains 1 cytochrome b5 heme-binding domain
Subcellular LocationMicrosome membrane ; Single- pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .
Tissue SpecificityExpressed at high levels in lung, liver, kidney and brain, low in testis and spleen. Not expressed in heart and skeletal muscle.