LMPD Database

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LMP013095

UniProt Annotations

Entry Information
Gene Namesulfotransferase family, cytosolic, 2B, member 1
Protein EntryST2B1_RAT
UniProt IDQ29YR5
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 ; Synonyms=SULT2B1b ; IsoId=Q29YR5-1; Sequence=Displayed; Name=2 ; Synonyms=SULT2B1a ; IsoId=Q29YR5-2; Sequence=VSP_052079;
Biophysicochemical PropertiesKinetic parameters: KM=8.9 uM for pregnenolone (isoform 2) ; KM=17.9 uM for dehydroepiandrosterone (DHEA) (isoform A) ; KM=1.7 uM for cholesterol (isoform 1) ;
Catalytic Activity3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids such as dehydroepiandrosterone. Isoform 1 is required for production of cholesterol sulfate essential for normal skin development whereas isoform 2 produces pregnenolone sulfate, an essential neurosteroid during development of the central nervous system (By similarity)
SimilarityBelongs to the sulfotransferase 1 family
Subcellular LocationCytoplasm . Microsome .
Tissue SpecificityIsoform 1 is expressed in skin and testis. Higher level of isoform 2 expressed in skin and intestine, moderate level in the kidney, low level in liver, stomach and placenta