LMPD Database

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LMP013168

UniProt Annotations

Entry Information
Gene Namedihydrolipoamide dehydrogenase
Protein EntryDLDH_RAT
UniProt IDQ6P6R2
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityProtein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ; Note=Binds 1 FAD per subunit. ;
FunctionLipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity)
MiscellaneousThe active site is a redox-active disulfide bond.
PtmTyrosine phosphorylated
SimilarityBelongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Subcellular LocationMitochondrion matrix .
SubunitHomodimer. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by non-covalent bonds (By similarity)