LMPD Database

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LMP013172

UniProt Annotations

Entry Information
Gene Namedihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Protein EntryODO2_RAT
UniProt IDQ01205
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivitySuccinyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S- succinyldihydrolipoyl)lysine.
CofactorName=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
FunctionThe 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
PathwayAmino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.
SimilarityBelongs to the 2-oxoacid dehydrogenase family
SimilarityContains 1 lipoyl-binding domain
Subcellular LocationMitochondrion.
SubunitForms a 24-polypeptide structural core with octahedral symmetry.