LMPD Database

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LMP013190

UniProt Annotations

Entry Information
Gene Namelow density lipoprotein receptor
Protein EntryLDLR_RAT
UniProt IDP35952
SpeciesRat
Comments
Comment typeDescription
DomainThe NPXY motif mediates the interaction with the clathrin adaptor DAB2 involved in receptor internalization
FunctionBinds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
PtmUbiquitinated by MYLIP leading to degradation
SimilarityBelongs to the LDLR family
SimilarityContains 3 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 6 LDL-receptor class B repeats
SimilarityContains 7 LDL-receptor class A domains
Subcellular LocationCell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit ; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus . Early endosome {ECO:0000250}. Late endosome . Cell surface {ECO:0000250}. Lysosome . Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9 (By similarity)
SubunitInteracts with LDLRAP1, ARRB1, SNX17. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts with the full length immature form of PCSK9 (via C-terminus) (By similarity)