LMPD Database

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LMP013220

UniProt Annotations

Entry Information
Gene Namearachidonate 12-lipoxygenase, epidermal
Protein EntryLX12E_RAT
UniProt IDD3ZQF9
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityArachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)- 12-hydroperoxyicosa-5,8,10,14-tetraenoate.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
FunctionNon-heme iron-containing dioxygenase that probably catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. May preferentially convert arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE
PathwayLipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
SimilarityBelongs to the lipoxygenase family
SimilarityContains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationCytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}.