LMPD Database

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LMP013255

UniProt Annotations

Entry Information
Gene Namesteroid 5 alpha-reductase 3
Protein EntryPORED_RAT
UniProt IDQ5RJM1
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5RJM1-1; Sequence=Displayed; Name=2; IsoId=Q5RJM1-2; Sequence=VSP_039791; Note=No experimental confirmation available.;
Catalytic ActivityA 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH
Catalytic ActivityDitrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH
FunctionPlays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT)
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityExpressed in the 2 tissues tested i.e. testis and liver