LMPD Database

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LMP013295

UniProt Annotations

Entry Information
Gene Nameinositol-trisphosphate 3-kinase C
Protein EntryIP3KC_RAT
UniProt IDQ80ZG2
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.2 uM for Ins(1,4,5)P3 ; KM=1.5 uM for Ins(2,4,5)P3 ; KM=33 uM for ATP ;
Catalytic ActivityATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Enzyme RegulationActivated by Ca(2+)/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4.
FunctionCan phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate
SimilarityBelongs to the inositol phosphokinase (IPK) family
Subcellular LocationNucleus . Cytoplasm . Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
Tissue SpecificityHighly expressed in tongue epithelium, taste papilla, heart, brain and testis. Weakly expressed in lung, liver and kidney