LMPD Database

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LMP013308

UniProt Annotations

Entry Information
Gene NameFCH domain only 2
Protein Entry
UniProt ID
SpeciesRat
Comments
Comment typeDescription
FunctionFunctions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor (By similarity). {ECO:0000250}.
PtmUbiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity). {ECO:0000250}.
SimilarityBelongs to the FCHO family. {ECO:0000305}.
SimilarityContains 1 FCH domain. {ECO:0000255|PROSITE- ProRule:PRU00083}.
SimilarityContains 1 MHD (mu homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00404}.
Subcellular LocationMembrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.
SubunitHomodimer; disulfide-linked. May form homotetramer. Interacts with AP2A1. Interacts with EPS15, EPS15R, ITSN1 and ITSN2; recruit those scaffolding proteins which in turn may interact with the adaptor protein complex AP-2 at the plasma membrane. Interacts with DAB2 (via DPF motifs); mediates LDL receptor/LDLR endocytosis (By similarity). {ECO:0000250}.
Tissue SpecificityUbiquitously expressed (at protein level). {ECO:0000269|PubMed:21762413}.