LMPD Database

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LMP013312

UniProt Annotations

Entry Information
Gene NameNAD(P) dependent steroid dehydrogenase-like
Protein EntryNSDHL_RAT
UniProt IDQ5PPL3
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityA 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) = a 3-oxosteroid + CO(2) + NAD(P)H.
FunctionInvolved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.
SimilarityBelongs to the 3-beta-HSD family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein . Lipid droplet . Note=Trafficking through the Golgi is necessary for ER membrane localization