LMPD Database

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LMP013313

UniProt Annotations

Entry Information
Gene NameRAR-related orphan receptor B
Protein Entry
UniProt ID
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage; Named isoforms=2; Name=2; Synonyms=ROR-beta 2; IsoId=P45446-2; Sequence=Displayed; Note=Shows a 4-fold higher transcriptional activation of an optimal promoter compared to isoform 1.; Name=1; Synonyms=ROR-beta 1; IsoId=P45446-1; Sequence=VSP_022577;
DomainAF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity (PubMed:8816759 and PubMed:11689423). {ECO:0000269|PubMed:11689423, ECO:0000269|PubMed:8816759}.
FunctionIsoform 1: Critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity). {ECO:0000250}.
FunctionNuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity. {ECO:0000269|PubMed:12958591, ECO:0000269|PubMed:8816759}.
InductionIsoform 2 oscillates diurnally in eye and pineal gland, with highest levels shortly after midnight. {ECO:0000269|PubMed:9729429}.
Sequence CautionSequence=AAA42095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitMonomer. Interacts with CRX. {ECO:0000269|PubMed:11689423, ECO:0000269|PubMed:12958591, ECO:0000269|PubMed:8816759}.
Tissue SpecificityIsoform 2 expressed with circadian rhythm in eye and pineal gland. Isoform 1 expressed in retina cortex, thalamus, and hypothalamus. {ECO:0000269|PubMed:9670004, ECO:0000269|PubMed:9729429}.