LMPD Database

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LMP013331

UniProt Annotations

Entry Information
Gene Namesphingomyelin synthase 2
Protein EntrySMS2_RAT
UniProt IDQ4JM44
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityA ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.
FunctionSphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity (By similarity)
PtmPalmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization
SimilarityBelongs to the sphingomyelin synthase family
Subcellular LocationCell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Note=Predominantly plasma membrane, some in Golgi apparatus
Tissue SpecificityExpression restricted to late round spermatids and elongating spermatids but not detected in late elongate spermatids and Sertoli cells (at protein level)