LMPD Database

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LMP013398

UniProt Annotations

Entry Information
Gene Nameabhydrolase domain containing 5
Protein EntryABHD5_RAT
UniProt IDQ6QA69
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
FunctionLysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation (By similarity)
InductionIncreased in the early stage of adipocyte differentiation
SimilarityBelongs to the peptidase S33 family. ABHD4/ABHD5 subfamily
Subcellular LocationCytoplasm . Lipid droplet . Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA.
SubunitInteracts with ADRP and PLIN. Interacts with PNPLA2 (By similarity). Interacts with PLIN5; promotes interaction with PNPLA2. {ECO:0000250, ECO:0000269|PubMed:15136565, ECO:0000269|PubMed:23408028}.