LMPD Database

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LMP013414

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase medium-chain family member 4
Protein EntryACSM4_RAT
UniProt IDQ7TN78
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Developmental StageDetected in all cell layers of the dorso- medial part of the embryonic olfactory placode and olfactory epithelium. First detected in olfactory placode on embryonic day 11.5. Detected in olfactory placode on embryonic day 12, 14, 16 and 18
FunctionHas medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro)
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family
Subcellular LocationMitochondrion matrix .
Tissue SpecificityDetected in adult olfactory epithelium