LMPD Database

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LMP013417

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group VI (cytosolic, calcium-independent)
Protein EntryPLPL9_RAT
UniProt IDP97570
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P97570-1; Sequence=Displayed; Name=Short; IsoId=P97570-2; Sequence=VSP_044365;
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Enzyme RegulationInhibited by calcium-activated calmodulin
FunctionCatalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods (By similarity)
SimilarityContains 1 patatin domain
SimilarityContains 7 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationIsoform Long: Membrane ; Peripheral membrane protein. Note=Recruited to the membrane- enriched pseudopod upon MCP1/CCL2 stimulation in monocytes
Subcellular LocationIsoform Short: Cytoplasm .
Tissue SpecificityFound in brain, lung, spleen, kidney, liver, heart and skeletal muscle.