LMPD Database

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LMP013441

UniProt Annotations

Entry Information
Gene Namelysophosphatidylcholine acyltransferase 1
Protein EntryPCAT1_RAT
UniProt IDQ1HAQ0
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
DomainThe di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine
Enzyme RegulationNot activated by inflammatory stimulation. Inhibited by Cu(2+) and Fe(2+). Activity is not affected by Co(2+), Mg(2+) or Mn(2+) (By similarity)
FunctionPossesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology
InductionBy FGF7
PathwayLipid metabolism; phospholipid metabolism.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
SimilarityContains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet . Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm
Tissue SpecificityEnriched in alveolar type II cells of lung. Also highly expressed in stomach. {ECO:0000269|PubMed:16704971, ECO:0000269|PubMed:16864775}.