LMPD Database

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LMP013491

UniProt Annotations

Entry Information
Gene Nameprostaglandin E synthase 3 (cytosolic)
Protein EntryTEBP_RAT
UniProt IDP83868
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate
FunctionCytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (By similarity). {ECO:0000250|UniProtKB:Q15185, ECO:0000269|PubMed:10922363}.
InductionIn brain, by LPS
PathwayLipid metabolism; prostaglandin biosynthesis
Sequence CautionSequence=CK475788; Type=Frameshift; Positions=156; Evidence= ;
SimilarityBelongs to the p23/wos2 family
SimilarityContains 1 CS domain. {ECO:0000255|PROSITE- ProRule:PRU00547}.
Subcellular LocationCytoplasm .
SubunitBinds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation
Tissue SpecificityWidely expressed with highest levels in testis