LMPD Database

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LMP013649

UniProt Annotations

Entry Information
Gene NameABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
Protein EntryBGAT2_RAT
UniProt IDQ8CFC4
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityUDP-alpha-D-galactose + alpha-L-fucosyl- (1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L- fucosyl-(1->2))-D-galactosyl-R.
Catalytic ActivityUDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L- fucosyl-(1->2))-beta-D-galactose.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 1 Mn(2+) ion per subunit. ;
DomainThe conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.
FunctionPosseses strong B transferase activity and a weak A transferase activity
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 6 family
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity)
Tissue SpecificityLarge intestine, caecum, stomach, pancreas, submaxillary gland and kidney (at protein level). Ubiquitous. {ECO:0000269|PubMed:12180981, ECO:0000269|PubMed:12237302, ECO:0000269|PubMed:12799344}.