LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP014429

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group I, member 3
Protein EntryNR1I3_MACMU
UniProt IDQ8MIM3
SpeciesRhesus monkey
Comments
Comment typeDescription
DomainComposed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
FunctionBinds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).
PtmPhosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
Sequence CautionSequence=AAM76230.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Cytoplasm Cytoplasm, cytoskeleton Note=Recruited to the cytoplasm by DNAJC7.
SubunitHeterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90 (By similarity).