LMPD Database

LMP014722

Gene Information

Entrez Gene ID	705121
Gene Name	phosphatase and tensin homolog
Gene Symbol	PTEN
Species	Macaca mulatta

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0043220	IEA:Ensembl	C	Schmidt-Lanterman incisure
GO:0005737	IEA:Ensembl	C	cytoplasm
GO:0009898	IEA:Ensembl	C	cytoplasmic side of plasma membrane
GO:0035749	IEA:Ensembl	C	myelin sheath adaxonal region
GO:0043005	IEA:Ensembl	C	neuron projection
GO:0005634	IEA:Ensembl	C	nucleus
GO:0051717	IEA:Ensembl	F	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287	IEA:InterPro	F	magnesium ion binding
GO:0016314	IEA:InterPro	F	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800	IEA:InterPro	F	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438	IEA:Ensembl	F	phosphatidylinositol-3-phosphatase activity
GO:0004722	IEA:Ensembl	F	protein serine/threonine phosphatase activity
GO:0004725	IEA:InterPro	F	protein tyrosine phosphatase activity
GO:0008138	IEA:InterPro	F	protein tyrosine/serine/threonine phosphatase activity
GO:0007092	IEA:Ensembl	P	activation of mitotic anaphase-promoting complex activity
GO:0001525	IEA:Ensembl	P	angiogenesis
GO:0060070	IEA:Ensembl	P	canonical Wnt signaling pathway
GO:0048738	IEA:Ensembl	P	cardiac muscle tissue development
GO:0032286	IEA:Ensembl	P	central nervous system myelin maintenance
GO:0021955	IEA:Ensembl	P	central nervous system neuron axonogenesis
GO:0060997	IEA:Ensembl	P	dendritic spine morphogenesis
GO:0021542	IEA:Ensembl	P	dentate gyrus development
GO:0043542	IEA:Ensembl	P	endothelial cell migration
GO:0048853	IEA:Ensembl	P	forebrain morphogenesis
GO:0046855	IEA:InterPro	P	inositol phosphate dephosphorylation
GO:0007611	IEA:Ensembl	P	learning or memory
GO:0045475	IEA:Ensembl	P	locomotor rhythm
GO:0060291	IEA:Ensembl	P	long-term synaptic potentiation
GO:0060179	IEA:Ensembl	P	male mating behavior
GO:0042711	IEA:Ensembl	P	maternal behavior
GO:0033555	IEA:Ensembl	P	multicellular organismal response to stress
GO:2000134	IEA:Ensembl	P	negative regulation of G1/S transition of mitotic cell cycle
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0050771	IEA:Ensembl	P	negative regulation of axonogenesis
GO:0090344	IEA:Ensembl	P	negative regulation of cell aging
GO:0030336	IEA:InterPro	P	negative regulation of cell migration
GO:0045792	IEA:Ensembl	P	negative regulation of cell size
GO:0031658	IEA:Ensembl	P	negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0061002	IEA:Ensembl	P	negative regulation of dendritic spine morphogenesis
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0090394	IEA:Ensembl	P	negative regulation of excitatory postsynaptic membrane potential
GO:0051895	IEA:InterPro	P	negative regulation of focal adhesion assembly
GO:0031642	IEA:Ensembl	P	negative regulation of myelination
GO:0046621	IEA:Ensembl	P	negative regulation of organ growth
GO:0051898	IEA:Ensembl	P	negative regulation of protein kinase B signaling
GO:0090071	IEA:Ensembl	P	negative regulation of ribosome biogenesis
GO:2000808	IEA:Ensembl	P	negative regulation of synaptic vesicle clustering
GO:0007270	IEA:Ensembl	P	neuron-neuron synaptic transmission
GO:0046856	IEA:InterPro	P	phosphatidylinositol dephosphorylation
GO:2001235	IEA:Ensembl	P	positive regulation of apoptotic signaling pathway
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:2000463	IEA:Ensembl	P	positive regulation of excitatory postsynaptic membrane potential
GO:2000060	IEA:Ensembl	P	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091	IEA:Ensembl	P	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107	IEA:Ensembl	P	postsynaptic density assembly
GO:0060134	IEA:Ensembl	P	prepulse inhibition
GO:0097105	IEA:Ensembl	P	presynaptic membrane assembly
GO:0060736	IEA:Ensembl	P	prostate gland growth
GO:0043491	IEA:Ensembl	P	protein kinase B signaling
GO:0050821	IEA:Ensembl	P	protein stabilization
GO:0002902	IEA:Ensembl	P	regulation of B cell apoptotic process
GO:0033032	IEA:Ensembl	P	regulation of myeloid cell apoptotic process
GO:0060024	IEA:Ensembl	P	rhythmic synaptic transmission
GO:0035176	IEA:Ensembl	P	social behavior
GO:0060074	IEA:Ensembl	P	synapse maturation

KEGG Pathway Links

KEGG Pathway ID	Description
ko05213	Endometrial cancer
mcc05213	Endometrial cancer
ko04510	Focal adhesion
mcc04510	Focal adhesion
mcc04068	FoxO signaling pathway
ko05214	Glioma
mcc05214	Glioma
mcc05161	Hepatitis B
ko00562	Inositol phosphate metabolism
mcc00562	Inositol phosphate metabolism
ko05218	Melanoma
mcc05218	Melanoma
ko05206	MicroRNAs in cancer
mcc05206	MicroRNAs in cancer
ko04151	PI3K-Akt signaling pathway
mcc04151	PI3K-Akt signaling pathway
mcc05200	Pathways in cancer
ko04070	Phosphatidylinositol signaling system
mcc04070	Phosphatidylinositol signaling system
ko05215	Prostate cancer
mcc05215	Prostate cancer
ko05222	Small cell lung cancer
mcc05222	Small cell lung cancer
ko04530	Tight junction
mcc04530	Tight junction
ko04150	mTOR signaling pathway
mcc04150	mTOR signaling pathway
ko04115	p53 signaling pathway
mcc04115	p53 signaling pathway