LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP011438

UniProt Annotations

Entry Information
Gene Namevery-long-chain enoyl-CoA reductase
Protein EntryECR_ARATH
UniProt IDQ9M2U2
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + NADP(+) = a very- long-chain trans-2,3-dehydroacyl-CoA + NADPH.
Disruption PhenotypeAbnormal organ morphology and stem glossiness. {ECO:0000269|PubMed:15829606}.
FunctionEnoyl-CoA reductase responsible for the second reduction step in very long-chain fatty acids (VLCFAs) synthesis. Required for the elongation of fatty acids precursors of sphingolipids, storage lipids and cuticular waxes. {ECO:0000269|PubMed:14673020, ECO:0000269|PubMed:15829606}.
PathwayLipid metabolism; fatty acid biosynthesis.
SimilarityBelongs to the steroid 5-alpha reductase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:15829606}; Multi-pass membrane protein {ECO:0000269|PubMed:15829606}.
SubunitPart of the fatty acid elongase complex which contains a beta-ketoacyl-CoA synthase (KCS), a beta-ketoacyl-CoA reductase (KCR), a beta-hydroxyacyl-CoA dehydratase (HCD) and an enoyl-CoA reductase (ECR). {ECO:0000305}.
Tissue SpecificityExpressed in roots, leaves, stems, flowers and siliques. Detected in mature seeds. {ECO:0000269|PubMed:14673020}.