LMPD Database

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LMP000405

UniProt Annotations

Entry Information
Gene Nameapolipoprotein C-II
Protein EntryAPOC2_HUMAN
UniProt IDP02655
SpeciesHuman
Comments
Comment typeDescription
DiseaseHyperlipoproteinemia 1B (HLPP1B) [MIM
FunctionComponent of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.
PtmProapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
PtmProapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
SimilarityBelongs to the apolipoprotein C2 family.
Subcellular LocationSecreted .
Tissue SpecificityLiver and intestine.