LMPD Database

LMP000416

Record overview

LMPD ID	LMP000416
Gene ID	116519
Species	Homo sapiens (Human)
Gene Name	apolipoprotein A-V
Gene Symbol	APOA5
Synonyms	APOAV; RAP3
Alternate names	apolipoprotein A-V; apo-AV; apolipoprotein A5; regeneration-associated protein 3
Chromosome	11
Map Location	11q23
Summary	The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]
Orthologs	View orthologs and multiple alignments for APOA5

Proteins

apolipoprotein A-V precursor

Refseq ID:	NP_001160070
Protein GI:	262231737
UniProt ID:	Q6Q788
mRNA ID:	NM_001166598
Length:	366
RefSeq Status:	REVIEWED

apolipoprotein A-V precursor
`MASMAAVLTWALALLSAFSATQARKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEEL EEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVS GIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFT RAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP`

Refseq ID:	NP_443200
Protein GI:	63079709
UniProt ID:	Q6Q788
mRNA ID:	NM_052968
Length:	366
RefSeq Status:	REVIEWED

Protein sequence is identical to GI:262231737 (mRNA isoform)

sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2326
peptide sequence: 
MASMAAVLTWALALLSAFSATQA

mat_peptide: 24..366
product: apolipoprotein A-V
calculated_mol_wt: 38905
peptide sequence: 
RKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLE
GLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPAR
LSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSA
FAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP

sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2326
peptide sequence: 
MASMAAVLTWALALLSAFSATQA

mat_peptide: 24..366
product: apolipoprotein A-V
calculated_mol_wt: 38905
peptide sequence: 
RKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLE
GLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPAR
LSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSA
FAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP