LMPD Database

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LMP000416

UniProt Annotations

Entry Information
Gene Nameapolipoprotein A-V
Protein EntryAPOA5_HUMAN
UniProt IDQ6Q788
SpeciesHuman
Comments
Comment typeDescription
CautionIt is uncertain whether Met-1 or Met-4 is the initiator.
DiseaseHyperlipoproteinemia 5 (HLPP5) [MIM
DiseaseHypertriglyceridemia, familial (FHTR) [MIM
FunctionMinor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. {ECO
InductionUp-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates).
MiscellaneousInduced in early phase of liver regeneration.
PolymorphismThree common alleles are known: allele APOA5*1, APOA5*2 and APOA5*3. The APOA5*2 haplotype, which consists of 3 non-coding SNPs, is present in approximately 16% of Caucasians and is associated with increased plasma triglyceride concentrations. APOA5*3 haplotype is defined by the rare Ser-19-Trp substitution. Together, the APOA5*2 and APOA5*3 haplotypes are found in 25 to 50% of African Americans, Hispanics, and Caucasians.
PtmPhosphorylation sites are present in the extracellular medium.
Sequence CautionSequence=AAF25661.1; Type=Erroneous initiation; Evidence= ; Sequence=AAF25662.1; Type=Erroneous initiation; Evidence= ; Sequence=AAQ89109.1; Type=Erroneous termination; Positions=275; Note=Translated as Gln.; Evidence= ;
SimilarityBelongs to the apolipoprotein A1/A4/E family.
Subcellular LocationSecreted .
SubunitInteracts with GPIHBP1.
Tissue SpecificityLiver and plasma. {ECO