LMPD Database

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LMP000448

Record overview

LMPD IDLMP000448
Gene ID5724
SpeciesHomo sapiens (Human)
Gene Nameplatelet-activating factor receptor
Gene SymbolPTAFR
SynonymsPAFR
Chromosome1
Map Location1p35-p34.3
SummaryThis gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for PTAFR

Proteins

platelet-activating factor receptor
Refseq ID:NP_001158193
Protein GI:257900488
UniProt ID:P25105
mRNA ID:NM_001164721
Length:342
RefSeq Status:REVIEWED
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFIN
TYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFL
IILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
 
platelet-activating factor receptor
Refseq ID:NP_000943
Protein GI:4506241
UniProt ID:P25105
mRNA ID:NM_000952
Length:342
RefSeq Status:REVIEWED
Protein sequence is identical to GI:257900488 (mRNA isoform)
 
platelet-activating factor receptor
Refseq ID:NP_001158194
Protein GI:257900491
UniProt ID:P25105
mRNA ID:NM_001164722
Length:342
RefSeq Status:REVIEWED
Protein sequence is identical to GI:257900488 (mRNA isoform)
 
platelet-activating factor receptor
Refseq ID:NP_001158195
Protein GI:257900493
UniProt ID:P25105
mRNA ID:NM_001164723
Length:342
RefSeq Status:REVIEWED
Protein sequence is identical to GI:257900488 (mRNA isoform)