LMPD Database

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LMP000546

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 4, subfamily F, polypeptide 12
Protein EntryCP4FC_HUMAN
UniProt IDQ9HCS2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HCS2-1; Sequence=Displayed; Name=2; IsoId=Q9HCS2-2; Sequence=VSP_055581, VSP_055582; Note=No experimental confirmation available.;
Catalytic ActivityRH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
CofactorName=heme; Xref=ChEBI
FunctionCatalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.
Sequence CautionSequence=EAW84492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane {ECO
Tissue SpecificityExpressed in small intestine, liver, colon and heart.