LMPD Database

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LMP000760

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group H, member 2
Protein EntryNR1H2_HUMAN
UniProt IDP55055
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55055-1; Sequence=Displayed; Name=2; IsoId=P55055-2; Sequence=VSP_053789; Note=No experimental confirmation.;
FunctionNuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).
InteractionO95477:ABCA1; NbExp=2; IntAct=EBI-745354, EBI-784112; Q99750:MDFI; NbExp=3; IntAct=EBI-745354, EBI-724076;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus {ECO
SubunitForms a heterodimer with RXR.
Tissue SpecificityUbiquitous.