LMPD Database

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LMP000936

UniProt Annotations

Entry Information
Gene Namephospholipase C, beta 1 (phosphoinositide-specific)
Protein EntryPLCB1_HUMAN
UniProt IDQ9NQ66
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q9NQ66-1; Sequence=Displayed; Name=B; IsoId=Q9NQ66-2; Sequence=VSP_004718;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI
DiseaseEpileptic encephalopathy, early infantile, 12 (EIEE12) [MIM
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
MiscellaneousThe receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.
Sequence CautionSequence=BAA25507.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAB14641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityContains 1 C2 domain. {ECO
SimilarityContains 1 PI-PLC X-box domain. {ECO
SimilarityContains 1 PI-PLC Y-box domain. {ECO
Subcellular LocationNucleus membrane . Cytoplasm . Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
SubunitInteracts with DGKQ.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLCB1ID41742ch20p12.html";