LMPD Database

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LMP000979

UniProt Annotations

Entry Information
Gene Namecolipase, pancreatic
Protein EntryCOL_HUMAN
UniProt IDP04118
SpeciesHuman
Comments
Comment typeDescription
FunctionColipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
FunctionEnterostatin has a biological activity as a satiety signal.
PolymorphismVariant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes.
SimilarityBelongs to the colipase family. {ECO
Subcellular LocationSecreted.
SubunitForms a 1:1 stoichiometric complex with pancreatic lipase.
Tissue SpecificityExpressed by the pancreas.
Web ResourceName=Wikipedia; Note=Colipase entry; URL="http://en.wikipedia.org/wiki/Colipase";