LMPD Database

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LMP001075

UniProt Annotations

Entry Information
Gene Namesterol carrier protein 2
Protein EntryNLTP_HUMAN
UniProt IDQ59HG9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage, Alternative splicing; Named isoforms=8; Name=SCPx; IsoId=P22307-1; Sequence=Displayed; Name=SCP2; IsoId=P22307-2; Sequence=VSP_018977; Note=Contains a mitochondrial transit peptide at positions 1-20. ; Name=3; IsoId=P22307-3; Sequence=VSP_042686, VSP_042687; Name=4; IsoId=P22307-4; Sequence=VSP_045187; Note=Produced by alternative splicing. No experimental confirmation available.; Name=5; IsoId=P22307-5; Sequence=VSP_018977, VSP_047269, VSP_047270; Name=6; IsoId=P22307-6; Sequence=VSP_018977, VSP_047268; Name=7; IsoId=P22307-7; Sequence=VSP_042686; Note=Produced by alternative splicing.; Name=8; IsoId=P22307-8; Sequence=VSP_047267; Note=Produced by alternative splicing.;
Catalytic Activity3-alpha,7-alpha,12-alpha-trihydroxy-5-beta- cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha- trihydroxy-24-oxo-5-beta-cholestanoyl-CoA.
DiseaseLeukoencephalopathy, with dystonia and motor neuropathy (LDMN) [MIM
FunctionMediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
InductionUp-regulated by 4-hydroxy-tamoxifen.
InteractionQ03135:CAV1; NbExp=3; IntAct=EBI-1050999, EBI-603614; P49817:Cav1 (xeno); NbExp=3; IntAct=EBI-1050999, EBI-1161338;
Sequence CautionSequence=AAA03558.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityContains 1 SCP2 domain.
SimilarityIn the N-terminal section; belongs to the thiolase family.
Subcellular LocationCytoplasm . Mitochondrion . Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.
Subcellular LocationIsoform SCP2: Mitochondrion .
Subcellular LocationIsoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import.
SubunitInteracts with PEX5.
Tissue SpecificityLiver, fibroblasts, and placenta.