LMPD Database

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LMP001184

UniProt Annotations

Entry Information
Gene Namesterol O-acyltransferase 2
Protein EntrySOAT2_HUMAN
UniProt IDO75908
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=ACAD2a; IsoId=O75908-1; Sequence=Displayed; Name=2; Synonyms=ACAD2b; IsoId=O75908-2; Sequence=VSP_057159; Note=Lower enzymatic activity; Name=3; Synonyms=ACAD2c; IsoId=O75908-3; Sequence=VSP_057158, VSP_057160; Note=Lower enzymatic activity; Name=4; IsoId=O75908-4; Sequence=VSP_057161, VSP_057162; Note=No experimental confirmation available;
Catalytic ActivityAcyl-CoA + cholesterol = CoA + cholesterol ester.
FunctionPlays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
SimilarityBelongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitMay form homo- or heterodimers.
Tissue SpecificityExpression seems confined in hepatocytes and enterocytes.