LMPD Database

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LMP001889

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group H, member 3
Protein EntryB4DXU5_HUMAN
UniProt IDQ13133
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13133-1; Sequence=Displayed; Name=2; IsoId=Q13133-2; Sequence=VSP_003664; Note=No experimental confirmation available.; Name=3; IsoId=Q13133-3; Sequence=VSP_044960; Note=No experimental confirmation available.;
FunctionNuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).
InductionBy 9-cis retinoic acid (9CRA).
InteractionO60869:EDF1; NbExp=4; IntAct=EBI-781356, EBI-781301; O60341:KDM1A; NbExp=2; IntAct=EBI-781356, EBI-710124; Q15788:NCOA1; NbExp=14; IntAct=EBI-781356, EBI-455189; O43463:SUV39H1; NbExp=2; IntAct=EBI-781356, EBI-349968;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus {ECO
SubunitHeterodimer of LXRA and RXR.
Tissue SpecificityVisceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.