LMPD Database

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LMP002064

UniProt Annotations

Entry Information
Gene Nameprostaglandin E synthase
Protein EntryPTGES_HUMAN
UniProt IDO14684
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate.
CofactorName=glutathione; Xref=ChEBI
FunctionCatalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
InductionBy p53/TP53.
SimilarityBelongs to the MAPEG family.
Subcellular LocationMembrane ; Multi-pass membrane protein .
SubunitHomotrimer.