LMPD Database

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LMP002081

UniProt Annotations

Entry Information
Gene NameUDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Protein EntryB4GT1_MOUSE
UniProt IDP15535
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative initiation; Named isoforms=2; Name=Long; Synonyms=Cell surface; IsoId=P15535-1; Sequence=Displayed; Name=Short; Synonyms=Golgi complex; IsoId=P15535-2; Sequence=VSP_018803;
Catalytic ActivityUDP-alpha-D-galactose + D-glucose = UDP + lactose.
Catalytic ActivityUDP-alpha-D-galactose + N-acetyl-beta-D- glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N- acetyl-beta-D-glucosaminylglycopeptide.
Catalytic ActivityUDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Developmental StageIn the brain, highest levels of expression are found at 11.5 dpc with decreased expression thereafter. {ECO:0000269|PubMed:11145975}.
FunctionThe cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
FunctionThe Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
PathwayProtein modification; protein glycosylation.
PtmThe soluble form derives from the membrane forms by proteolytic processing.
SimilarityBelongs to the glycosyltransferase 7 family. {ECO:0000305}.
Subcellular LocationIsoform Long: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cell surface. Note=Found in trans cisternae of Golgi.
Subcellular LocationIsoform Short: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Found in trans cisternae of Golgi.
Subcellular LocationProcessed beta-1,4-galactosyltransferase 1: Secreted. Note=Soluble form found in body fluids.
SubunitHomodimer; and heterodimer with alpha-lactalbumin to form lactose synthase.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=b4GalT1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_460";